Your hormone therapy treatment

Your hormone therapy treatment

Hormone therapy blocks the action of hormones which encourage tumour cells to grow, therefore limiting tumour-cell growth.

It is only prescribed for hormone-dependent tumours such as breast or prostate cancer.

It is often complementary to other cancer treatments such as chemotherapy, surgery or radiotherapy.

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What is hormone therapy?

It is a treatment which inhibits the formation or action of the hormone which feeds some types of tumour cells.

The cells of these tumours have receptors (proteins) which attach to hormones such as oestrogen or progesterone and depend on them to grow. These drugs either block this union or decrease the body’s hormone levels.

The tumour is destroyed or reduced, improving survival and quality of life.

What type of tumours are treated with hormone therapy?

Hormone-dependent tumours which depend on hormones for growth are usually:

  • Breast cancer
  • Prostate cancer

Other cancers such as those of the endometrium or ovary, or neuroendocrine tumours can also be treated with hormone therapy.

Usually we need to find out if the cancer cells have hormone receptors, to do this a biopsy (extraction of a piece of tumour) is required. If the specimen presents these receptors, then this treatment may work.

What is treatment like?

It can be given:

  • Prior to surgery (as neoadjuvant therapy),

    with the aim of reducing the size of the tumour to enable its removal. This treatment often lasts 3-6 months prior to surgery.

  • After surgery or radiotherapy (adjuvant therapy)

    to reduce the risk of recurrence. Treatment duration is often 5 to 10 years.

  • Treatment of disseminated disease,

    to control symptoms or prevent disease progression. Treatment duration depends on the progression of the disease and how well it responds to treatment.

Hormone therapy in breast cancer

Women’s hormones change throughout their life, the amount and origin of oestrogen varies depending on the stage of a woman’s reproductive life.

  • In premenopausal women:

    The amount of oestrogen is high and is generally produced by the ovaries.

  • Treatment:

  • Antioestrogens:

  • They impede the union of oestrogens and oestrogen receptors (ER) in the cancer cells.
  • They inhibit the growth of the tumour.
  • Induction of menopause

  • bloqueo de hormonas

  • Surgical:

  • Through extraction or irradiation of the ovaries, permanently eradicating ovarian function.
  • Chemical:

  • Drugs that interfere with the pituitary gland (in the brain), responsible for stimulating the ovaries to produce oestrogen (LHRH).
  • This can be reversible.
  • Administration: subcutaneous or intramuscular once a month.
  • In post-menopausal women:

    Oestrogen is lower, produced by the adrenal glands and body fat due to the action of an enzyme called aromatase.

  • Treatment:

  • Aromatase inhibitors:

  • Impede the production of oestrogens through aromatase, reducing levels in the blood.
  • Oral administration.

Hormone therapy in prostate cancer

The aim is to reduce the number of male hormones (androgens) which help cancer cells to grow.

Themajority of prostate cancers present androgen receptors.

Androgens are mainly produced in the testicles in the form of testosterone, and in a small part in the adrenal glands.

bloqueo hormona

Orchidectomy:

  • Partial excision of the testicles, removing only the part where testosterone is produced.
  • Drug treatment:

  • LHRH analogues: act on the pituitary gland (brain) to prevent stimulation of hormone production. Administered through periodic injection.
  • Antiandrogens: prevent androgens produced in the adrenal glands from acting on the prostate.
  • Side effects of hormone therapy

    Side effects depend greatly on the drug administered and how your body reacts.

    They may be:

    • Side effects in breast cancer:
    • Skin dryness
    • Vaginal dryness,
    • Flushing,
    • Decreased libido,
    • Tendency to weight gain.
    • Side effects in prostate cancer:
    • Erectile dysfunction (impotence),
    • Weight gain,
    • Breast growth,
    • Decreased libido,
    • Tiredness.

    Other treatments

    Immunotherapy

    Inmunotherapy

    Boost your immune system. Your own immune cells kill tumor cells.

    targeted therapy_precision_medicine

    Targeted therapy

    They interfere with specific alterations present in tumor cells. Directly to your mutation type.

    chemotherapy_marbella

    Chemotherapy

    Destroy the cell from within. Attacks rapidly dividing and growing cells.

    Surgery

    Cancer surgery

    Attacks the tumor locally. It can be diagnostic, curative, or palliative. It usually complements other treatments.

    radiotherapy

    Radiotherapy

    It affects the part of the body where radiation is applied to kill cancer cells and stop them from growing and reproducing.

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    Do not entertain doubts

    Get a second medical opinion

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    Team up with your doctor

    Your oncology team that will clarify all your doubts about the disease. Don’t be afraid to ask.

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    Pruebas diagnósticas

    A good diagnosis is the key to accurate treatment.

    Would you like more information?

    We can contact you, or if you prefer, call us on 952 908 898

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